E-ISSN 2146-3077
Original Article
Distribution of Immunoglobulin Isotypes and IgG Subclasses in Visceral Leishmaniasis Cases
1 Celal Bayar Üniversitesi Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı  
2 Celal Bayar Üniversitesi Tıp Fakültesi, Parazitoloji Anabilim Dalı, Manisa, Türkiye  
3 Ege University Medical School, Department of Parasitology, Bornova, Izmir, Turkey  
4 Ege Üniversitesi Tıp Fakültesi, Parazitoloji Anabilim Dalı, İzmir, Türkiye  
Turkiye Parazitol Derg 2004; 28: 73-76

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Key Words: Visceral leishmaniasis, immunoglobulins, IgG subclasses
Abstract

Visceral leishmaniasis, a fatal tropical disease, remains problematic as early diagnosis is difficult and treatment often results in drug resistance and relapse. In this study, relative levels of immunoglobulin G (IgG), IgM, IgA, IgE, and IgG subclasses were analyzed in 29 visceral leishmaniasis patients. Compared to 30 controls, visceral leishmaniasis patients showed a significantly higher IgG response. Among IgG subclasses, IgG1 response was significantly higher in visceral leishmaniasis patients than in the controls. Therefore, monitoring of immunoglobulin isotypes and IgG subclasses in visceral leishmaniasis patients may be a good serologic alternative in monitoring the disease status.

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