ABSTRACT

Objective:

The first aim of the present study was to determine the efficiency of A. absinthium extract on cats naturally infected with Toxocara cati. The second aim was to determine the efficiency of the extract on the embryonic development of T. cati eggs in vitro.

Methods:

Artemisia absinthium extract was orally administrated to cats at the doses of 300 mg/kg and 600 mg/kg body weight in Group 1 and 2, respectively. It was given only once a day and the treatment continued 7 consecutive days. The faeces of the cats were examined both macroscopically and microscopically by flotation procedure with saturated salt solution pre-, during and post- treatment period. The faecal analysis was maintained during 8 days after completing the extract administration. The alteration of faecal egg numbers was performed by using the McMaster technique.

Results:

The faecal egg numbers per gram were decreased gradually in cats in the trial groups. In the treatment period, the activities of ALT, AST, ALP, urea and creatinine were located within the physiological ranges in cats. In in vitro trials with A. absinthium extract, the embryonic development of T. cati eggs was identical in all groups (treatment and control). A. absinthium extract did not inhibit larval development in eggs in in vitro trials.

Conclusion:

This plant extract may be an alternative choice in the treatment of parasitic diseases in future.