Comparison of the Effects of Local and Uncontrolled Levamisole Preparations on Mice Naturally Infected with Aspiculuris tetraptera
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Original Investigation
P: 112-114
June 2007

Comparison of the Effects of Local and Uncontrolled Levamisole Preparations on Mice Naturally Infected with Aspiculuris tetraptera

Turkiye Parazitol Derg 2007;31(2):112-114
1. Yenisehir İbrahim Orhan Vocational School, Uludağ University, Bursa
2. Yüzüncü Yıl University, Veterinary Faculty Department of Farmocology and Toxicology, Van, Turkey
3. Yüzüncü Yıl University, Department of Parasitology, Van, Turkey
4. Yüzüncü Yıl University, Department of Internal Diseases, Van, Turkey
5. Yüzüncü Yıl University, Medical Faculty Department of Farmacology Van, Turkey
No information available.
No information available
Received Date: 01.02.2006
Accepted Date: 05.03.2007
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ABSTRACT

This study was performed to compare effectiveness of two levamisole preparations prepared in two different countries (Iran and Turkey) in mice naturally infected with Aspiculuris tetraptera. For this purpose, natural infection was diagnosed using the cellophane tape method on the perianal region and centrifugal flotation technique on the feces of mice obtained from the experimental Animal Unit of the Faculty of Medicine, University of Yüzüncü Yıl, Van. Mice naturally infected with A. tetraptera were then divided in three groups. Animals in Group 1 (8 animals) received levamisole prepared in Iran, animals in Group 2 (8 animals) received levamisole prepared in Turkey and animals in Group 3 (6 animals) were used as untreated controls. Both levamisole preparations were used in a 10 mg/kg dose. After drug administrations, stool samples of the animals in all groups were examined for seven days. On the eighth day, the animals were humanely destroyed using inhalation anesthesia. After euthanasia, parasites in the intestine were also counted. As a result; levamisole coming through uncontrolled border trade from Iran was 69.3% effective against A. tetraptera and the levamisole prepared in Turkey was 91.7% effective in naturally infected mice. Results obtained from this study compared statistically and the differences were found to be significant (p<0.001).

Keywords: Levamisole, A. tetraptera, Mouse, anthelmintic effect

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